TRPM1 forms ion channels associated with melanin content in melanocytes.

  title={TRPM1 forms ion channels associated with melanin content in melanocytes.},
  author={Elena Oancea and Joris Vriens and Sebasti{\'a}n Brauchi and Janice C Jun and Igor Splawski and David E Clapham},
  journal={Science signaling},
  volume={2 70},
TRPM1 (melastatin), which encodes the founding member of the TRPM family of transient receptor potential (TRP) ion channels, was first identified by its reduced expression in a highly metastatic mouse melanoma cell line. Clinically, TRPM1 is used as a predictor of melanoma progression in humans because of its reduced abundance in more aggressive forms of melanoma. Although TRPM1 is found primarily in melanin-producing cells and has the molecular architecture of an ion channel, its function is… CONTINUE READING


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