TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome.

@article{Mir2012TRPC6GV,
  title={TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome.},
  author={Sevgi Mir and Onder Yavaşcan and Afig Huseyinov Berdeli and Betul Sozeri},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2012},
  volume={27 1},
  pages={205-9}
}
BACKGROUND In steroid-resistant nephrotic syndrome (SRNS), a considerable number of patient progress to end-stage renal disease (ESRD), despite aggressive therapy. The latest advance in familial focal segmental glomerulosclerosis (FSGS) has been the discovery of a mutant form of canonical transient receptor potential channel 6 (TRPC6) leading to FSGS through unclear mechanisms. The aim of this study is to screen for TRPC6 mutations in familial and sporadic SRNS patients. METHODS Twenty-five… CONTINUE READING