TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling.

@article{Kuwahara2006TRPC6FA,
  title={TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling.},
  author={Koichiro Kuwahara and Yanggan Wang and John McAnally and J. A. Richardson and Rhonda Bassel-Duby and Joseph A Hill and Eric N Olson},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 12},
  pages={
          3114-26
        }
}
The heart responds to injury and chronic pressure overload by pathologic growth and remodeling, which frequently result in heart failure and sudden death. Calcium-dependent signaling pathways promote cardiac growth and associated changes in gene expression in response to stress. The calcium/calmodulin-dependent phosphatase calcineurin, which signals to nuclear factor of activated T cells (NFAT) transcription factors, serves as a transducer of calcium signals and is sufficient and necessary for… CONTINUE READING

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