TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.

@article{Ilatovskaya2015TRPC6CA,
  title={TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.},
  author={Daria V. Ilatovskaya and Alexander Staruschenko},
  journal={American journal of physiology. Renal physiology},
  year={2015},
  volume={309 5},
  pages={F393-7}
}
Podocytes (terminally differentiated epithelial cells of the glomeruli) play a key role in the maintenance of glomerular structure and permeability and in the incipiency of various renal abnormalities. Injury to podocytes is considered a major contributor to the development of kidney disease as their loss causes proteinuria and progressive glomerulosclerosis. The physiological function of podocytes is critically dependent on proper intracellular calcium handling; excessive calcium influx in… CONTINUE READING

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