TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle.

@article{Vohra2013TRPC3RR,
  title={TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle.},
  author={Pawan Kumar Vohra and Michael Allen Thompson and Venkatachalem Sathish and Alexander Kiel and Calvin R. Jerde and Christina M. Pabelick and Brij B. Singh and Y S Prakash},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1833 12},
  pages={
          2953-2960
        }
}
Exogenous brain-derived neurotrophic factor (BDNF) enhances Ca(2+) signaling and cell proliferation in human airway smooth muscle (ASM), especially with inflammation. Human ASM also expresses BDNF, raising the potential for autocrine/paracrine effects. The mechanisms by which ASM BDNF secretion occurs are not known. Transient receptor potential channels (TRPCs) regulate a variety of intracellular processes including store-operated Ca(2+) entry (SOCE; including in ASM) and secretion of factors… CONTINUE READING
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