TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

Abstract

Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly adapting (RA) mechanosensitive currents to intermediate-adapting currents in dorsal root ganglion sensory neurons… (More)
DOI: 10.1098/rsob.120068

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@inproceedings{Quick2012TRPC3AT, title={TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells}, author={Kathryn S. Quick and Jing Zhao and Niels Eijkelkamp and John E. Linley and François Rugiero and James J. Cox and Ramin Raouf and Martine Gringhuis and Jane E. Sexton and J. D. Abramowitz and Ruth D. T. Taylor and Andy Forge and Jonathan Ashmore and Nerissa K. Kirkwood and Corn{\'e} J Kros and Guy P Richardson and Marc Freichel and Veit Flockerzi and Lutz Birnbaumer and J. N. Wood}, booktitle={Open biology}, year={2012} }