TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

@inproceedings{Quick2012TRPC3AT,
  title={TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells},
  author={Kathryn Quick and Jing Zhao and Niels Eijkelkamp and John E. Linley and François Rugiero and James J Cox and Ramin Raouf and Martine Gringhuis and Jane E Sexton and Joel Abramowitz and Ruth C. Taylor and Andy Forge and Jonathan Ashmore and Nerissa K. Kirkwood and Corn{\'e} J Kros and Guy P Richardson and Marc Freichel and Veit Flockerzi and Lutz Birnbaumer and John N Wood},
  booktitle={Open biology},
  year={2012}
}
Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly adapting (RA) mechanosensitive currents to intermediate-adapting currents in dorsal root ganglion sensory neurons. Deletion of both TRPC3 and TRPC6 caused deficits in light touch and silenced half of small-diameter sensory neurons expressing mechanically… CONTINUE READING
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