TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.

@article{Poteser2006TRPC3AT,
  title={TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.},
  author={Michael Poteser and Annarita Graziani and Christian Rosker and Petra Eder and Isabella Derler and Heike Kahr and Michael Xi Zhu and Christoph Romanin and Klaus Groschner},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 19},
  pages={13588-95}
}
Canonical transient receptor potential proteins (TRPC) have been proposed to form homo- or heteromeric cation channels in a variety of tissues, including the vascular endothelium. Assembly of TRPC multimers is incompletely understood. In particular, heteromeric assembly of distantly related TRPC isoforms is still a controversial issue. Because we have previously suggested TRPC proteins as the basis of the redox-activated cation conductance of porcine aortic endothelial cells (PAECs), we set out… CONTINUE READING

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