TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.

  title={TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.},
  author={Tsukasa Shimauchi and Takuro Numaga-Tomita and Tomoya Ito and Akiyuki Nishimura and Ryosuke Matsukane and Sayaka Oda and Sumio Hoka and Tomomi Ide and Norimichi Koitabashi and Koji Uchida and Hideki Sumimoto and Yasuo Mori and Motohiro Nishida},
  journal={JCI insight},
  volume={2 15}
Myocardial atrophy is a wasting of cardiac muscle due to hemodynamic unloading. Doxorubicin is a highly effective anticancer agent but also induces myocardial atrophy through a largely unknown mechanism. Here, we demonstrate that inhibiting transient receptor potential canonical 3 (TRPC3) channels abolishes doxorubicin-induced myocardial atrophy in mice. Doxorubicin increased production of ROS in rodent cardiomyocytes through hypoxic stress-mediated upregulation of NADPH oxidase 2 (Nox2), which… CONTINUE READING
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