TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding.

@article{Rao2006TRPC1FA,
  title={TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding.},
  author={Jaladanki N Rao and Oleksandr Platoshyn and Vera A. Golovina and Lan Liu and Tongtong Zou and Bernard S. Marasa and Douglas J. Turner and Jason X.-J. Yuan and Jian-Ying Wang},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={290 4},
  pages={
          G782-92
        }
}
An increase in cytosolic free Ca(2+) concentration ([Ca(2+)](cyt)) results from Ca(2+) release from intracellular stores and extracellular Ca(2+) influx through Ca(2+)-permeable ion channels and is crucial for initiating intestinal epithelial restitution to reseal superficial wounds after mucosal injury. Capacitative Ca(2+) entry (CCE) induced by Ca(2+) store depletion represents a major Ca(2+) influx mechanism, but the exact molecular components constituting this process remain elusive. This… 

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