TRPC1 forms the stretch-activated cation channel in vertebrate cells

@article{Maroto2005TRPC1FT,
  title={TRPC1 forms the stretch-activated cation channel in vertebrate cells},
  author={Rosario Maroto and Albert Raso and Thomas Wood and Alex Kurosky and Boris Martinac and Owen P. Hamill},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={179-185}
}
The mechanosensitive cation channel (MscCa) transduces membrane stretch into cation (Na+, K+, Ca2+ and Mg2+) flux across the cell membrane, and is implicated in cell-volume regulation, cell locomotion, muscle dystrophy and cardiac arrhythmias. However, the membrane protein(s) that form the MscCa in vertebrates remain unknown. Here, we use an identification strategy that is based on detergent solubilization of frog oocyte membrane proteins, followed by liposome reconstitution and evaluation by… CONTINUE READING
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