TRPC1 channels are critical for hypertrophic signaling in the heart.

@article{Seth2009TRPC1CA,
  title={TRPC1 channels are critical for hypertrophic signaling in the heart.},
  author={Malini Seth and Zhu-Shan Zhang and Lan Mao and Victoria Graham and Jarrett L. Burch and Jonathan Stiber and Leonidas Tsiokas and Michelle P. Winn and Joel Abramowitz and Howard A Rockman and Lutz Birnbaumer and Paul Rosenberg},
  journal={Circulation research},
  year={2009},
  volume={105 10},
  pages={
          1023-30
        }
}
RATIONALE Cardiac muscle adapts to increase workload by altering cardiomyocyte size and function resulting in cardiac hypertrophy. G protein-coupled receptor signaling is known to govern the hypertrophic response through the regulation of ion channel activity and downstream signaling in failing cardiomyocytes. OBJECTIVE Transient receptor potential canonical (TRPC) channels are G protein-coupled receptor operated channels previously implicated in cardiac hypertrophy. Our objective of this… CONTINUE READING

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