TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma.

@article{Beck2008TRPCCD,
  title={TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma.},
  author={Benjamin Beck and V'yacheslav Lehen'kyi and Morad Roudbaraki and Matthieu Flourakis and Marie Charv{\'e}ron and Pascal Bordat and Renata Polakowska and Natalia Prevarskaya and Roman Skryma},
  journal={Cell calcium},
  year={2008},
  volume={43 5},
  pages={492-505}
}
Aberrant keratinocyte differentiation is considered to be a key mechanism in the onset of hyperproliferative dermatological diseases, including basal cell carcinoma (BCC). It is, therefore, vital to understand what drives keratinocytes to develop such pathological phenotypes. The role of calcium in keratinocyte differentiation is uncontested but the mechanisms controlling calcium-induced differentiation have yet to be completely elucidated. This study was designed to investigate the role of… CONTINUE READING

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