TRPC channels as STIM1-regulated SOCs.

  title={TRPC channels as STIM1-regulated SOCs.},
  author={Joseph P. Yuan and Min Seuk Kim and Weizhong Zeng and Dong Min Shin and Guo N. Huang and Paul F Worley and Shmuel Muallem},
  volume={3 4},
Store-operated Ca(2+) channels (SOCs) are Ca(2+) influx channels at the plasma membrane whose opening is determined by the level of Ca(2+) stored in the endoplasmic reticulum lumen. SOCs are activated in response to receptor-mediated or passive depletion of ER Ca(2+) to regulate many Ca(2+)-dependent cellular functions. Early work implicated the TRPC channels as SOCs. More recently, it was found that the Orai channels mediate the CRAC current and that the Ca(2+) binding protein STIM1 functions… CONTINUE READING

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