TRPC channels and their splice variants are essential for promoting human ovarian cancer cell proliferation and tumorigenesis.

@article{Zeng2013TRPCCA,
  title={TRPC channels and their splice variants are essential for promoting human ovarian cancer cell proliferation and tumorigenesis.},
  author={Bo Zeng and Cunzhong Yuan and Xingsheng Yang and Stephen L Atkin and S G Xu},
  journal={Current cancer drug targets},
  year={2013},
  volume={13 1},
  pages={103-16}
}
TRPC channels are Ca²⁺-permeable cationic channels controlling Ca²⁺ influx response to the activation of G protein-coupled receptors and protein tyrosine kinase pathways or the depletion of Ca²⁺ stores. Here we aimed to investigate whether TRPC can act as the potential therapeutic targets for ovarian cancer. The mRNAs of TRPC1, TRPC3, TRPC4 and TRPC6 were detected in human ovarian adenocarcinoma. The spliced variants of TRPC1β, TRPC3a, TRPC4β, TRPC4γ, and TRPC6 with exon 3 and 4 deletion were… CONTINUE READING
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