TRPC Channels As Effectors of Cardiac Hypertrophy

  title={TRPC Channels As Effectors of Cardiac Hypertrophy},
  author={Petra Eder and Jeffery D. Molkentin},
  journal={Circulation Research},
Transient receptor potential (TRP) channels of multiple subclasses are expressed in the heart, although their functions are only now beginning to emerge, especially for the TRPC subclass that appears to regulate the cardiac hypertrophic response. Although TRP channels permeate many different cations, they are most often ascribed a specific biological function because of Ca2+ influx, either for microdomain signaling or to reload internal Ca2+ stores in the endoplasmic reticulum through a store… 

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