TRPC 6 is a glomerular slit diaphragm-associated channel required for normal renal function

@inproceedings{Reiser2005TRPC6I,
  title={TRPC 6 is a glomerular slit diaphragm-associated channel required for normal renal function},
  author={Jochen Reiser and Krishna R Polu and Clemens C. M{\"o}ller and Peter Kenlan and Mehmet M Altintas and Changli Wei and Christian Faul and Stephanie Herbert and I Amat Villegas and Carmen {\'A}vila-Casado and MARY F. MCGEE and Hikaru Sugimoto and Dennis Brown and Raghu Kalluri and Peter H. Mundel and Paula L. Smith and David E Clapham and Martin R. Pollak},
  year={2005}
}
NATURE GENETICS ADVANCE ONLINE PUBLICATION 1 Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the permeability barrier in the kidney. Mutations in genes encoding structural proteins of the podocyte lead to the development of proteinuria, resulting in progressive kidney failure and focal segmental glomerulosclerosis. Here, we show that the canonical… CONTINUE READING

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A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

Winn, M.P
Science, published online • 2005

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