TRPA1 underlies a sensing mechanism for O2.

  title={TRPA1 underlies a sensing mechanism for O2.},
  author={Nobuaki Takahashi and Tomoyuki Kuwaki and Shigeki Kiyonaka and Tomohiro Numata and Daisuke Kozai and Yusuke Mizuno and Shinichiro Yamamoto and Shinji Naito and Ellen Knevels and Peter Carmeliet and Toru Oga and Shuji Kaneko and Seiji Suga and T Nokami and Jun-Ichi Yoshida and Yasuo Mori},
  journal={Nature chemical biology},
  volume={7 10},
Oxygen (O(2)) is a prerequisite for cellular respiration in aerobic organisms but also elicits toxicity. To understand how animals cope with the ambivalent physiological nature of O(2), it is critical to elucidate the molecular mechanisms responsible for O(2) sensing. Here our systematic evaluation of transient receptor potential (TRP) cation channels using reactive disulfides with different redox potentials reveals the capability of TRPA1 to sense O(2). O(2) sensing is based upon disparate… CONTINUE READING
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