TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

@inproceedings{McGaraughty2010TRPA1MO,
  title={TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats},
  author={Steve P McGaraughty and Katharine L. Chu and Richard J Perner and Stan DiDomenico and Michael Kort and Philip R. Kym},
  booktitle={Molecular pain},
  year={2010}
}
BACKGROUND There is growing evidence supporting a role for TRPA1 receptors in the neurotransmission of peripheral mechanical stimulation. In order to enhance understanding of TRPA1 contributions to mechanotransmission, we examined the effects a selective TRPA1 receptor antagonist, A-967079, on spinal neuronal activity following peripheral mechanical stimulation in uninjured, CFA-inflamed, and osteoarthritc (OA) rats. RESULTS Systemic injection of A-967079 (30 micromol/kg, i.v.) decreased the… CONTINUE READING