TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.

@article{Andersson2011TRPA1MS,
  title={TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.},
  author={David A Andersson and Clive Gentry and Lisa Alenmyr and Dan Killander and Simon E Lewis and Anders Andersson and Bernard Bucher and J Galzi and O lov Sterner and Stuart Bevan and Edward D H{\"o}gest{\"a}tt and Peter M Zygmunt},
  journal={Nature communications},
  year={2011},
  volume={2},
  pages={551}
}
TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics. Here we show that the antinociceptive effects of spinal and systemic administration of acetaminophen (paracetamol) are lost in Trpa1(-/-) mice. The electrophilic metabolites N-acetyl-p-benzoquinoneimine and p-benzoquinone, but not acetaminophen itself, activate mouse and human TRPA1. These… CONTINUE READING
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