TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus.

@article{Yu2009TRPA1IM,
  title={TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus.},
  author={Shaoyong Yu and Guofeng Gao and Blaise Z. Peterson and Ann Ouyang},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={297 1},
  pages={
          G34-42
        }
}
Sensitization of esophageal sensory afferents by inflammatory mediators plays an important role in esophageal nociception. We have shown esophageal mast cell activation induces long-lasting mechanical hypersensitivity in vagal nodose C-fibers. However, the roles of mast cell mediators and downstream ion channels in this process are unclear. Mast cell tryptase via protease-activated receptor 2 (PAR2)-mediated pathways sensitizes sensory nerves and induces hyperalgesia. Transient receptor… CONTINUE READING
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