TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.

@article{Shigetomi2013TRPA1CA,
  title={TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.},
  author={Eiji Shigetomi and Olan Jackson-Weaver and Robert T R Huckstepp and Thomas J O'Dell and Baljit S. Khakh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 24},
  pages={10143-53}
}
Astrocytes are found throughout the brain where they make extensive contacts with neurons and synapses. Astrocytes are known to display intracellular Ca(2+) signals and release signaling molecules such as D-serine into the extracellular space. However, the role(s) of astrocyte Ca(2+) signals in hippocampal long-term potentiation (LTP), a form of synaptic plasticity involved in learning and memory, remains unclear. Here, we explored a recently discovered novel TRPA1 channel-mediated… CONTINUE READING
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TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

  • E Shigetomi, X Tong, KY Kwan, DP Corey, BS Khakh
  • Nat Neurosci
  • 2012
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