TRPA1 agonists evoke coughing in guinea pig and human volunteers.

  title={TRPA1 agonists evoke coughing in guinea pig and human volunteers.},
  author={Mark A Birrell and Maria G Belvisi and Megan Grace and Laura Rachel Sadofsky and S. I. Faruqi and David J. Hele and Sarah A. Maher and V{\'e}ronique Freund-Michel and Alyn H. Morice},
  journal={American journal of respiratory and critical care medicine},
  volume={180 11},
RATIONALE Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is also increasing concern about their use in children. Environmental irritants such as air pollution and cigarette smoke are thought to evoke cough by stimulating airway sensory nerves; however, how this occurs is not fully understood. OBJECTIVES We… CONTINUE READING


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