TRPA1 agonists delay gastric emptying in rats through serotonergic pathways

@article{Doihara2009TRPA1AD,
  title={TRPA1 agonists delay gastric emptying in rats through serotonergic pathways},
  author={Hitoshi Doihara and Katsura Nozawa and Eri Kawabata-Shoda and Ryosuke Kojima and Toshihide Yokoyama and Hiroyuki Ito},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={380},
  pages={353-357}
}
Our recent study found that TRPA1 is highly expressed in enterochromaffin cells and that stimulation of these cells with TRPA1 agonists enhances 5-hydroxytryptamine (5-HT) secretion in vitro. Here, to demonstrate the 5-HT-releasing effect of TRPA1 agonists in vivo, we examined the effect of TRPA1 agonists on gastric emptying in rats. The results showed that TRPA1 agonists dose-dependently delayed gastric emptying. Further, the effects of TRPA1 agonists on this delay were abolished in rats… CONTINUE READING
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