TRP ion channels in the nervous system

@article{Moran2004TRPIC,
  title={TRP ion channels in the nervous system},
  author={Magdalene M Moran and Haoxing Xu and David E. Clapham},
  journal={Current Opinion in Neurobiology},
  year={2004},
  volume={14},
  pages={362-369}
}
The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families: classical (TRPC), vanilloid (TRPV), melastatin (TRPM), muclopins (TRPML), polycystin (TRPP), and ANKTM1 (TRPA). In the peripheral nervous system, stimuli including temperature, pressure, inflammatory… 
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Molecular Mechanisms of TRPV1 Channel Activation
TLDR
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References

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TLDR
It is demonstrated here that TRPC1 and TRPC5 are subunits of a heteromeric neuronal channel, and proposed that many TRPC heteromers form diverse receptor-regulated nonselective cation channels in the mammalian brain.
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TLDR
This review summarizes the current knowledge about the mechanism of activation of the TRPC3/6/7 subfamily, as well as the potential role of these proteins as components of native Ca2+-permeant channels.
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TLDR
It is proposed that hTRPV3 is thermosensitive in the physiological range of temperatures between TRPM8 and TRPV1.
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TLDR
A novel member of the transient receptor potential (Trp) family of ion channels, Trp12, was identified and the intron placement within that primary structure does not correlate with the previously postulated splice sites in transcripts encoding the stretch‐inhibitable channel.
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TLDR
This work describes the cloning and characterization of TRPM8, a distant relative of VR1 that is specifically expressed in a subset of pain- and temperature-sensing neurons and implicates an expanded role for this family of ion channels in somatic sensory detection.
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TLDR
It is demonstrated that TRPM5 and TRPM4b represent the first examples of voltage-modulated, Ca(2+)-activated, monovalent cation channels (VCAMs), and the voltage modulation and rapid kinetics provideTRPM5 with an excellent set of properties for participating in signaling in taste receptors and other excitable cells.
TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i
TLDR
TRPM5 is demonstrated to be a monovalent-specific, nonselective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca2+ ions and can be activated physiologically by inositol 1,4,5-trisphosphate-producing receptor agonists, and it may therefore couple intracellular Ca2+.
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TLDR
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TLDR
The distinct spatial patterns of TRP isoforms implicate that neurons are highly heterogeneous in receptor-activated Ca2+ influx responsible for the second phase of PI-mediated rise in intracellular Ca2+.
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TLDR
It is demonstrated that another member of the TRP family, TRPV4, previously described as a hypo-osmolarity-activated ion channel, also can be activated by heat and observed TRPv4 immunoreactivity in anterior hypothalamic structures involved in temperature sensation and the integration of thermal and osmotic information, which implicate TRpV4 as a possible transducer of warm stimuli within the hypothalamus.
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