TRP channels and the control of vascular function.

  title={TRP channels and the control of vascular function.},
  author={Anke Di and Asrar B. Malik},
  journal={Current opinion in pharmacology},
  volume={10 2},
Mammalian TRP channels are grouped into six subfamilies (TRPC, TRPM, TRPV, TRPA, TRPP, and TRPML) based on the homology of the amino acid sequence. They are nonselective cation-permeable channels, most of which are permeable for Ca(2+). Growing evidence demonstrates important roles of TRP channel in controlling vascular function including endothelial permeability, responses to oxidative stress, myogenic tone, cellular proliferative activity, and thermoregulation. TRP channels are activated by a… CONTINUE READING


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