TRP channels and calcium entry in human platelets.

  title={TRP channels and calcium entry in human platelets.},
  author={Stewart O. Sage and Sharon L Brownlow and Juan Antonio Rosado},
  volume={100 12},
  pages={4245-6; author reply 4246-7}
An elevation in cytosolic calcium concentration ([Ca2 ]i) plays a central role in the physiologic activation of platelets. Although a number of calcium entry pathways are believed to exist in human platelets,1 information on the identity of the channels concerned is limited. The recent paper by Hassock and colleagues,2 which attempts to characterize the expression of homologues of the Drosophila transient receptor potential channel (TRPC) mutant in platelets, is thus valuable in this respect… CONTINUE READING
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Endogenous Trp 1 conducts storemediated Ca 2  entry in human platelets

  • JA Rosado, SO Sage
  • J Physiol
  • 2001

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