TRP-channel-specific cutaneous eicosanoid release patterns

@article{Jain2011TRPchannelspecificCE,
  title={TRP-channel-specific cutaneous eicosanoid release patterns},
  author={Anila B. Jain and Simone Br{\"o}nneke and Ludger Kolbe and Franz St{\"a}b and Horst Wenck and Gitta Neufang},
  journal={PAIN},
  year={2011},
  volume={152},
  pages={2765-2772}
}
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TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

The role of TRPV1 and TRPA1 in the modulation of inflammatory genes that leads to or maintains CNI in sensory neurons and non-neuronal skin cells is discussed.

Epidermal expression of human TRPM8, but not of TRPA1 ion channels, is associated with sensory responses to local skin cooling.

The present observations demonstrating a lack of association of TRPA1 channel expression with cold sensitivity related measures reinforce doubts about involvement of this channel in cold pain in humans.

The role of transient receptor potential A 1 (TRPA1) in the development and maintenance of carrageenan-induced hyperalgesia

Transient Receptor Potential Ankyrin 1 (TRPA1)—An Inflammation-Induced Factor in Human HaCaT Keratinocytes

Findings point to an inflammatory role for TRPA1 in keratinocytes and present TRPA 1 as a potential drug target in inflammatory skin diseases.

Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes

It is shown for the first time that TRPA1 is expressed in primary human OA chondrocytes and its expression is increased following stimulation with inflammatory factors IL-1β, IL-17, LPS, and resistin.

TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers

The observation that the TRPA1 irritant cinnamaldehyde induced heat hyperalgesia at an effect sizes comparable with that of capsaicin attributes TRPA 1 a role in human heat-induced pain suggests the inclusion of heat pain as a major efficacy measure in human experimental studies of the effects ofTRPA1 antagonists and the development of TRPA2 antagonists for clinical pain settings involving heat hyperAlgesia.

TRP channels in the skin

This review focuses on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions and describes the putative involvement of several TRPannels in the development of certain skin diseases.

Allyl isothiocyanate sensitizes TRPV1 to heat stimulation

Findings demonstrate that TRPV1 is a locus for cross sensitization between AITC and heat in sensory neurons and may help explaining, at least in part, the role of this channel in A ITC-induced hyperalgesia to heat.

TRP channels in skin: from physiological implications to clinical significances

Not only act in sensory processing, TRP channels also contribute to epidermal differentiation, proliferation, barrier integration, skin regeneration, and immune responses and might be good therapeutic targets in diseases with aberrantTRP channels.

TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

The results strongly suggest that TRPA1 contributes, in a COX-dependent manner, to the development of acute inflammation, and demonstrates a hitherto unknown role of TRPA 1 in carrageenan-induced inflammatory edema.
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References

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