TRP Channels in Drug Discovery

@inproceedings{Szallasi2012TRPCI,
  title={TRP Channels in Drug Discovery},
  author={Arpad Szallasi and Tam{\'a}s B{\'i}r{\'o}},
  booktitle={Methods in Pharmacology and Toxicology},
  year={2012}
}
Transient receptor potential (TRP) is a large superfamily of cation channels comprising 28 members in mammals. TRP channels are ubiquitously expressed in human tissues, including the cardiovascular system where they have been associated with a number of physiological functions, such as proliferation, contraction, and migration. TRP channels comprise six large families of cation channels: TRPC, TRPM, TRPV, TRPP, TRPA, and TRPML with diverse ion selectivities and modes of activation. Depending on… CONTINUE READING

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