TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi

  title={TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi},
  author={U. Pal and X. Li and T. Wang and Ruth R. Montgomery and N. Ramamoorthi and Aravinda M. deSilva and Fukai Bao and Xiaofeng Yang and M. Pypaert and D. Pradhan and F. Kantor and S. Telford and J. Anderson and E. Fikrig},
  • U. Pal, X. Li, +11 authors E. Fikrig
  • Published 2004
  • Biology, Medicine
  • Cell
  • The Lyme disease agent Borrelia burgdorferi naturally persists in a cycle that primarily involves ticks and mammals. We have now identified a tick receptor (TROSPA) that is required for spirochetal colonization of Ixodes scapularis. B. burgdorferi outer surface protein A, which is abundantly expressed on spirochetes within the arthropod and essential for pathogen adherence to the vector, specifically bound to TROSPA. TROSPA mRNA levels in ticks increased following spirochete infestation and… CONTINUE READING
    359 Citations

    Figures and Topics from this paper

    Functional Insights into Recombinant TROSPA Protein from Ixodes ricinus
    • 15
    • Highly Influenced
    • PDF
    Identification of TROSPA homologue in Ixodes persulcatus Schulze, the specific vector for human Lyme borreliosis in Japan.
    • 16
    • Highly Influenced
    Interactions between Borrelia burgdorferi and ticks
    • 10
    • PDF
    Interaction of the Lyme disease spirochete with its tick vector
    • 62
    Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle
    • 38
    • PDF
    Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva.
    • 71
    • PDF
    Tick-host-pathogen interactions in Lyme borreliosis.
    • 123
    • PDF


    Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A.
    • 233
    • PDF
    Borrelia burgdorferi OspA is an arthropod-specific transmission- blocking Lyme disease vaccine
    • 420
    • PDF
    OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands.
    • 339
    • PDF
    Disruption of Ixodes scapularis anticoagulation by using RNA interference.
    • 115
    • PDF
    Inhibition of Borrelia burgdorferi-Tick Interactions In Vivo by Outer Surface Protein A Antibody1
    • 74
    • PDF
    Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding.
    • 241
    Essential Role for OspA/B in the Life Cycle of the Lyme Disease Spirochete
    • 293
    • PDF
    Borrelia burgdorferi Gene Expression In Vivo and Spirochete Pathogenicity
    • 83
    • PDF
    Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks.
    • 291
    • PDF