• DOI:10.1016/j.cell.2004.10.027
Corpus ID: 3846937

TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi

@article{Pal2004TROSPAAI,
  title={TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi},
  author={U. Pal and X. Li and T. Wang and Ruth R. Montgomery and N. Ramamoorthi and Aravinda M. deSilva and Fukai Bao and Xiaofeng Yang and M. Pypaert and D. Pradhan and F. Kantor and S. Telford and J. Anderson and E. Fikrig},
  journal={Cell},
  year={2004},
  volume={119},
  pages={457-468}
}

U. Pal, X. Li, +11 authors E. Fikrig

Published 2004

Biology, Medicine

Cell

The Lyme disease agent Borrelia burgdorferi naturally persists in a cycle that primarily involves ticks and mammals. We have now identified a tick receptor (TROSPA) that is required for spirochetal colonization of Ixodes scapularis. B. burgdorferi outer surface protein A, which is abundantly expressed on spirochetes within the arthropod and essential for pathogen adherence to the vector, specifically bound to TROSPA. TROSPA mRNA levels in ticks increased following spirochete infestation and… CONTINUE READING

View on Elsevier

doi.org

Save to Library

Create Alert

Cite

Launch Research Feed