TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi

@article{Pal2004TROSPAAI,
  title={TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi},
  author={U. Pal and X. Li and T. Wang and Ruth R. Montgomery and N. Ramamoorthi and Aravinda M. deSilva and Fukai Bao and Xiaofeng Yang and M. Pypaert and D. Pradhan and F. Kantor and S. Telford and J. Anderson and E. Fikrig},
  journal={Cell},
  year={2004},
  volume={119},
  pages={457-468}
}
  • U. Pal, X. Li, +11 authors E. Fikrig
  • Published 2004
  • Biology, Medicine
  • Cell
  • The Lyme disease agent Borrelia burgdorferi naturally persists in a cycle that primarily involves ticks and mammals. We have now identified a tick receptor (TROSPA) that is required for spirochetal colonization of Ixodes scapularis. B. burgdorferi outer surface protein A, which is abundantly expressed on spirochetes within the arthropod and essential for pathogen adherence to the vector, specifically bound to TROSPA. TROSPA mRNA levels in ticks increased following spirochete infestation and… CONTINUE READING
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