TRONCO: an R package for the inference of cancer progression models from heterogeneous genomic data

@inproceedings{Sano2015TRONCOAR,
  title={TRONCO: an R package for the inference of cancer progression models from heterogeneous genomic data},
  author={Luca De Sano and Giulio Caravagna and Daniele Ramazzotti and Alex Graudenzi and Giancarlo Mauri and Bud Mishra and Marco Antoniotti},
  year={2015}
}
Motivation: We introduce TRONCO (TRanslational ONCOlogy), an open-source R package that implements the state-of-the-art algorithms for the inference of cancer progression models from (epi)genomic mutational profiles. TRONCO can be used to extract population-level models describing the trends of accumulation of alterations in a cohort of cross-sectional samples, e.g., retrieved from publicly available databases, and individual-level models that reveal the clonal evolutionary history in single… CONTINUE READING