TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque, negatively modulates TRIM5α activity.

@article{Na2014TRIMe7CypAAA,
  title={TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque, negatively modulates TRIM5α activity.},
  author={Lei Na and Yan-dong Tang and Jian-Dong Liu and Chang-qing Yu and Liu-Ke Sun and Yue-zhi Lin and Xuefeng Wang and Xiaojun Wang and Jian-hua Zhou},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={446 2},
  pages={470-4}
}
The existence of innate, host-specific restriction factors is a major obstacle to the development of nonhuman primate models for AIDS studies, and TRIM5α is one of the most important of these restriction factors. In recent years, a TRIM5 chimeric gene that was retrotransposed by a cyclophilin A (CypA) cDNA was identified in certain macaque species. The TRIM5α-CypA fusion protein, TRIMCyp, which was expressed in these monkeys, had lost its restriction ability toward HIV-1. We previously found… CONTINUE READING