TRIMU-5, a μ2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis

@article{Eisenberg1994TRIMU5A,
  title={TRIMU-5, a $\mu$2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis},
  author={Richard M. Eisenberg},
  journal={Pharmacology Biochemistry and Behavior},
  year={1994},
  volume={47},
  pages={943-946}
}
  • R. Eisenberg
  • Published 1 April 1994
  • Biology, Medicine
  • Pharmacology Biochemistry and Behavior

Cyclic endomorphin analogs in targeting opioid receptors to achieve pain relief.

Recent advances in obtaining endomorphin-based cyclic peptide analogs are summarized and cyclization can be viewed as an interesting option.

Effects of prenatal morphine on hypothalamic metabolism of neurotransmitters and gonadal and adrenal activities, during the early postnatal period in the rat

Investigation in newborn rats of the effects of prenatal morphine-exposure on the hypothalamic metabolism of norepinephrine, serotonin and neuropeptide Y and the activity of the hypothalamo-pituitary gonadal and adrenal axes found changes observed on hypothalamic metabolisms are temporally correlated with the early postnatal activation of the corticostimulating function in neonates of both sexes.

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DAMGO, a highly selective mu opioid agonist, is capable of stimulating the hypothalamo-pituitary-adrenal (HPA) axis to produce a dose-related elevation in plasma corticosterone (CS), and which of the mu receptors was involved using naloxonazine, a mu-1 receptor-selective antagonist was confirmed.

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  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
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