TRIM72 is required for effective repair of alveolar epithelial cell wounding.

@article{Kim2014TRIM72IR,
  title={TRIM72 is required for effective repair of alveolar epithelial cell wounding.},
  author={Seong Chul Kim and Thomas Kellett and Shaohua Wang and Miyuki Nishi and Nagaraja Nagre and Beiyun Zhou and Per Flodby and Konstantin Shilo and Samir N Ghadiali and Hiroshi Takeshima and Rolf D. Hubmayr and Xiaoli Zhao},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2014},
  volume={307 6},
  pages={L449-59}
}
The molecular mechanisms for lung cell repair are largely unknown. Previous studies identified tripartite motif protein 72 (TRIM72) from striated muscle and linked its function to tissue repair. In this study, we characterized TRIM72 expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. In vivo injury of lung cells was introduced by high tidal volume ventilation, and repair-defective cells were labeled with postinjury administration of propidium… CONTINUE READING