TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity.

@article{Song2005TRIM5alphaAW,
  title={TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity.},
  author={Byeongwoon Song and Felipe D{\'i}az-Griffero and Do Hyun Park and Thomas Rogers and Matthew H. Stremlau and Joseph Sodroski},
  journal={Virology},
  year={2005},
  volume={343 2},
  pages={201-11}
}
The tripartite motif (TRIM) protein, TRIM5alpha, restricts infection by particular retroviruses. Many TRIM proteins form cytoplasmic bodies of unknown function. We investigated the relationship between cytoplasmic body formation and the structure and antiretroviral activity of TRIM5alpha. In addition to diffuse cytoplasmic staining, the TRIM5alpha proteins from several primate species were located in cytoplasmic bodies of different sizes; by contrast, TRIM5alpha from spider monkeys did not form… CONTINUE READING

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