TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.

  title={TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.},
  author={Takeshi Kondo and Masashi Watanabe and Shigetsugu Hatakeyama},
  journal={Biochemical and biophysical research communications},
  volume={422 3},
Innate immune responses are triggered by pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs) and then activate intracellular signaling pathways including NF-κB and interferon regulatory factors. Recently, it has been reported that tripartite motif (TRIM) proteins function as crucial regulators via ubiquitin-mediated modifications for these signaling pathways. In this study, we showed that one of the TRIM family ubiquitin ligases, TRIM59, interacts with… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Control of FoxO4 Activity and Cell Survival by TRIM22 Directs TLR3-Stimulated Cells Toward IFN Type I Gene Induction or Apoptosis.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research • 2015


Publications referenced by this paper.
Showing 1-10 of 26 references


T. Pertel, S. Hausmann, +9 authors M. L. Albert
23 Strambio-De-Castillia, W. Mothes, M. Pizzato, M.G. Grutter, J. Luban, TRIM5 is an innate immune sensor for the retrovirus capsid lattice, Nature 472 • 2011
View 1 Excerpt

TRIM proteins and cancer

Nature Reviews Cancer • 2011
View 1 Excerpt

Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 2 Excerpts

Similar Papers

Loading similar papers…