TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.

@article{Kondo2012TRIM59IW,
  title={TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.},
  author={Takeshi Kondo and Masashi Watanabe and Shigetsugu Hatakeyama},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={422 3},
  pages={501-7}
}
Innate immune responses are triggered by pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs) and then activate intracellular signaling pathways including NF-κB and interferon regulatory factors. Recently, it has been reported that tripartite motif (TRIM) proteins function as crucial regulators via ubiquitin-mediated modifications for these signaling pathways. In this study, we showed that one of the TRIM family ubiquitin ligases, TRIM59, interacts with… CONTINUE READING

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