TRIM5 alpha Drives SIVsmm Evolution in Rhesus Macaques

  title={TRIM5 alpha Drives SIVsmm Evolution in Rhesus Macaques},
  author={Fan Wu and Andrea Kirmaier and Robert M Goeken and Ilnour Ourmanov and Laura R. Hall and Jennifer Sian Morgan and Kenta Matsuda and ALICIA J. BUCKLER-WHITE and Keiko Tomioka and Ronald J. Plishka and Sonya Whitted and Welkin E Johnson and Vanessa M Hirsch},
  booktitle={PLoS pathogens},
The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of the TRIM5α B30.2/SPRY domain impacted the level of SIVsmm viremia in rhesus macaques. Viremia in macaques homozygous for the non-restrictive TRIM5α allele TRIM5(Q) was significantly higher than in macaques expressing two restrictive TRIM5alpha alleles TRIM5(TFP/TFP) or TRIM5(Cyp/TFP). Using this model, we observed that despite an early… CONTINUE READING
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