TRIM29 negatively regulates p53 via inhibition of Tip60.

  title={TRIM29 negatively regulates p53 via inhibition of Tip60.},
  author={Takuya Sho and Tadasuke Tsukiyama and Tomonobu Sato and Takeshi Kondo and Jun Cheng and Takashi Saku and Masahiro Asaka and Shigetsugu Hatakeyama},
  journal={Biochimica et biophysica acta},
  volume={1813 6},
Ataxia-telangiectasia (AT) is an autosomal recessive genetic disease characterized by immunological deficiencies, neurological degeneration, developmental abnormalities and an increased risk of cancer. Ataxia-telangiectasia group D (ATDC) was initially described as a gene related to AT. Ataxia-telangiectasia group D, also known as TRIM29, is structurally a member of the tripartite motif (TRIM) family of proteins, some of which have been reported to be highly expressed in some human carcinomas… CONTINUE READING