TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release

@article{Bunch2014TRIM28RR,
  title={TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release},
  author={Heeyoun Bunch and Xiaofeng Zheng and Adam B. Burkholder and S. Dillon and S. Motola and G. Birrane and Christopher C. Ebmeier and S. Levine and D. Fargo and G. Hu and D. Taatjes and S. Calderwood},
  journal={Nature structural \& molecular biology},
  year={2014},
  volume={21},
  pages={876 - 883}
}
Promoter-proximal pausing of RNA polymerase II (Pol II) is a major checkpoint in transcription. An unbiased search for new human proteins that could regulate paused Pol II at the HSPA1B gene identified TRIM28. In vitro analyses indicated HSF1-dependent attenuation of Pol II pausing upon TRIM28 depletion, whereas in vivo data revealed de novo expression of HSPA1B and other known genes regulated by paused Pol II upon TRIM28 knockdown. These results were supported by genome-wide ChIP-sequencing… Expand
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