TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

@inproceedings{Fasching2015TRIM28RT,
  title={TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells},
  author={Liana Fasching and Adamandia Kapopoulou and Rohit Sachdeva and Rebecca Petri and Marie E J{\"o}nsson and Christian M{\"a}nne and Priscilla Turelli and Patric Jern and Florence Cammas and Didier Trono and Johan Jakobsson},
  booktitle={Cell reports},
  year={2015}
}
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, which is in contrast to other somatic cell types using DNA methylation. We also show that… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Effects of retroviruses on host genome function.

  • Annual review of genetics
  • 2008
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Repbase Update, a database of eukaryotic repetitive elements

  • Cytogenetic and Genome Research
  • 2005
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL