TRIM25 has a dual function in the p53/Mdm2 circuit

  title={TRIM25 has a dual function in the p53/Mdm2 circuit},
  author={Ping Zhang and Seham Elabd and Stefanie Hammer and Valeriya Solozobova and Hua Yan and Frank Bartel and Shuichiro Inoue and T Henrich and Joachim Wittbrodt and Felix Loosli and Gary Davidson and Christine Blattner},
P53 is an important tumor suppressor that, upon activation, induces growth arrest and cell death. Control of p53 is thus of prime importance for proliferating cells, but also for cancer therapy, where p53 activity contributes to the eradication of tumors. Mdm2 functionally inhibits p53 and targets the tumor suppressor protein for degradation. In a genetic screen, we identified TRIM25 as a novel regulator of p53 and Mdm2. TRIM25 increased p53 and Mdm2 abundance by inhibiting their ubiquitination… CONTINUE READING
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