TRIM25 has a dual function in the p53/Mdm2 circuit

@article{Zhang2015TRIM25HA,
  title={TRIM25 has a dual function in the p53/Mdm2 circuit},
  author={Ping Zhang and Seham Elabd and Stefanie Hammer and Valeriya Solozobova and Hua Yan and Frank Bartel and Shuichiro Inoue and T Henrich and Joachim Wittbrodt and Felix Loosli and Gary Davidson and Christine Blattner},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={5729-5738}
}
P53 is an important tumor suppressor that, upon activation, induces growth arrest and cell death. Control of p53 is thus of prime importance for proliferating cells, but also for cancer therapy, where p53 activity contributes to the eradication of tumors. Mdm2 functionally inhibits p53 and targets the tumor suppressor protein for degradation. In a genetic screen, we identified TRIM25 as a novel regulator of p53 and Mdm2. TRIM25 increased p53 and Mdm2 abundance by inhibiting their ubiquitination… CONTINUE READING
Highly Cited
This paper has 32 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Mdm2 facilitates the association of p53 with the proteasome.

Proceedings of the National Academy of Sciences of the United States of America • 2010

Regulation of p53--insights into a complex process.

Critical reviews in biochemistry and molecular biology • 2009

Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2008