TRIM24 links a noncanonical histone signature to breast cancer

@inproceedings{Tsai2010TRIM24LA,
  title={TRIM24 links a noncanonical histone signature to breast cancer},
  author={Wen-Wei Tsai and Zhanxin Wang and Teresa Tingting Yiu and Kadir Caner Akdemir and Weiya Xia and Stefan M. Winter and Cheng-Yu Edwin Tsai and Xiaobing Shi and Dirk Schwarzer and William Plunkett and Bruce J. Aronow and Or P Gozani and Wolfgang Fischle and Mien-Chie Hung and Dinshaw J. Patel and Michelle Craig Barton},
  booktitle={Nature},
  year={2010}
}
Recognition of modified histone species by distinct structural domains within ‘reader’ proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes. Here we report that chromatin regulator tripartite motif-containing 24 (TRIM24) functions in humans as a reader of dual histone marks by means of tandem plant homeodomain (PHD… CONTINUE READING
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