TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS.

@article{Xue2018TRIM21PI,
  title={TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS.},
  author={Binbin Xue and Huiyi Li and Mengmeng Guo and Jingjing Wang and Yan Xu and Xuan Zou and Rilin Deng and Guangdi Li and Haizhen Zhu},
  journal={Journal of virology},
  year={2018},
  volume={92 14}
}
Human innate immunity responds to viral infection by activating the production of interferons (IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a critical role in innate immune response to viral infection. In this study, we show that TRIM21 (tripartite motif-containing protein 21) interacts with MAVS to positively regulate innate immunity. Under viral infection, TRIM21 is upregulated through the IFN/JAK/STAT signaling pathway. Knockdown of TRIM21 dramatically… CONTINUE READING
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