TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

@inproceedings{Uchil2008TRIMEL,
  title={TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle},
  author={Pradeep Devappa Uchil and Brian D Quinlan and Wai-Tsing Chan and Joseph M Luna and Walther Mothes},
  booktitle={PLoS pathogens},
  year={2008}
}
Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HEK293 cells, affect the entry or release of human immunodeficiency virus 1 (HIV), murine leukemia virus (MLV), or avian leukosis virus (ALV). While TRIM11 and 31 inhibited HIV entry… CONTINUE READING
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