TRILOSTANE AND THE NORMAL HYPOTHALAMIC‐PITUITARY‐ADRENOCORTICAL AXIS

@article{Semple1982TRILOSTANEAT,
  title={TRILOSTANE AND THE NORMAL HYPOTHALAMIC‐PITUITARY‐ADRENOCORTICAL AXIS},
  author={C. Semple and J. Thomson and A. Stark and M. M. and and G. H. Beastall},
  journal={Clinical Endocrinology},
  year={1982},
  volume={17}
}
  • C. Semple, J. Thomson, +2 authors G. H. Beastall
  • Published 1982
  • Medicine
  • Clinical Endocrinology
  • Trilostane has been used to treat Cushing's syndrome and other adrenocortical disorders. To investigate its effect on the normal adrenal gland, trilostane (initially 240 mg/day) was given to ten healthy men, the dose increasing at weekly intervals by 240 mg/day up to a final dose of 960 mg/day. The drug was well tolerated although one subject withdrew after the first week because of gastrointestinal side effects. Trilostane had no significant effect on aldosterone levels or blood pressure. The… CONTINUE READING
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    References

    SHOWING 1-10 OF 16 REFERENCES
    Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis.
    • 109
    Effects of inhibition of adrenal steroidogenesis on compensation of fluid BEASTALL
    • 1981
    Treatment of Cushing ’ s syndrome in childhood with trilostane
    • 1981
    Trilostane interference with steroid DARLING. J.A.B
    • Journal of’Endocrinology,
    • 1981