• DOI:10.1111/j.1365-2265.1982.tb01629.x
Corpus ID: 13599891

TRILOSTANE AND THE NORMAL HYPOTHALAMIC‐PITUITARY‐ADRENOCORTICAL AXIS

@article{Semple1982TRILOSTANEAT,
  title={TRILOSTANE AND THE NORMAL HYPOTHALAMIC‐PITUITARY‐ADRENOCORTICAL AXIS},
  author={C. Semple and J. Thomson and A. Stark and M. M. and and G. H. Beastall},
  journal={Clinical Endocrinology},
  year={1982},
  volume={17}
}

C. Semple, J. Thomson, +2 authors G. H. Beastall

Published 1982

Medicine

Clinical Endocrinology

Trilostane has been used to treat Cushing's syndrome and other adrenocortical disorders. To investigate its effect on the normal adrenal gland, trilostane (initially 240 mg/day) was given to ten healthy men, the dose increasing at weekly intervals by 240 mg/day up to a final dose of 960 mg/day. The drug was well tolerated although one subject withdrew after the first week because of gastrointestinal side effects. Trilostane had no significant effect on aldosterone levels or blood pressure. The… CONTINUE READING

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