TRF4 is involved in polyadenylation of snRNAs in Drosophila melanogaster.

  title={TRF4 is involved in polyadenylation of snRNAs in Drosophila melanogaster.},
  author={Ryoichi Nakamura and Ryo Takeuchi and Kei-ichi Takata and Kaori Shimanouchi and Yoko Abe and Yoshihiro Kanai and Tatsushi Ruike and Ayumi Ihara and Kengo Sakaguchi},
  journal={Molecular and cellular biology},
  volume={28 21},
The Saccharomyces cerevisiae poly(A) polymerases Trf4 and Trf5 are involved in an RNA quality control mechanism, where polyadenylated RNAs are degraded by the nuclear exosome. Although Trf4/5 homologue genes are distributed throughout multicellular organisms, their biological roles remain to be elucidated. We isolated here the two homologues of Trf4/5 in Drosophila melanogaster, named DmTRF4-1 and DmTRF4-2, and investigated their biological function. DmTRF4-1 displayed poly(A) polymerase… CONTINUE READING