TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.

  title={TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.},
  author={Tomokazu Ohishi and Toru Hirota and Takashi Tsuruo and Hiroyuki Seimiya},
  journal={Cancer research},
  volume={70 5},
Aurora-A, a conserved serine-threonine kinase, plays essential roles in mitosis. Aberrant upregulation of Aurora-A perturbs proper mitotic progression and results in a generation of multinucleated cells with centrosome amplification. The molecular mechanisms for these mitotic defects remain elusive. Here, we show that the overexpressed Aurora-A-induced mitotic defects depend on the telomeric protein TRF1. Live and fixed cell analyses revealed that Aurora-A overexpression in HeLa cells… CONTINUE READING
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