TREX is a conserved complex coupling transcription with messenger RNA export

@article{Straesser2002TREXIA,
  title={TREX is a conserved complex coupling transcription with messenger RNA export},
  author={K. Straesser and S. Masuda and P. Mason and J. Pfannstiel and Marisa Oppizzi and S. Rodr{\'i}guez-Navarro and A. Rond{\'o}n and A. Aguilera and K. Struhl and R. Reed and E. Hurt},
  journal={Nature},
  year={2002},
  volume={417},
  pages={304-308}
}
  • K. Straesser, S. Masuda, +8 authors E. Hurt
  • Published 2002
  • Biology, Medicine
  • Nature
  • The essential yeast proteins Yra1 and Sub2 are messenger RNA export factors that have conserved counterparts in metazoans, designated Aly and UAP56, respectively. These factors couple the machineries that function in splicing and export of mRNA. Here we show that both Yra1 and Sub2 are stoichiometrically associated with the heterotetrameric THO complex, which functions in transcription in yeast. We also show that Sub2 and Yra1 interact genetically with all four components of the THO complex… CONTINUE READING

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