TREM2 sustains microglial expansion during aging and response to demyelination.

  title={TREM2 sustains microglial expansion during aging and response to demyelination.},
  author={Pietro Luigi Poliani and Y Claire Wang and Elena Fontana and Michelle L Robinette and Yoshinori Yamanishi and Susan Gilfillan and Marco Colonna},
  journal={The Journal of clinical investigation},
  volume={125 5},
Microglia contribute to development, homeostasis, and immunity of the CNS. Like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (TREM2), which binds polyanions, such as dextran sulphate and bacterial LPS, and activates downstream signaling cascades through the adapter DAP12. Individuals homozygous for inactivating mutations in TREM2 exhibit demyelination of subcortical white matter and a lethal early onset… CONTINUE READING
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