TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model


Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor that triggers intracellular protein tyrosine phosphorylation. Recent genome-wide association studies have shown that a rare R47H mutation of TREM2 correlates with a substantial increase in the risk of developing Alzheimer's disease (AD). To address the basis for this… (More)
DOI: 10.1016/j.cell.2015.01.049


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